Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment

Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment

  • Daly, B. et al. Misery Loves Company: Presenting Symptom Clusters to Urgent Care by Patients Receiving Antineoplastic Therapy. JCO Oncol. Pr. 14, e484–e495 (2018).

    Article 

    Google Scholar 

  • Adam, R. et al. Treatment burden in individuals living with and beyond cancer: A systematic review of qualitative literature. PLoS One 18, e0286308 (2023).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Henry, D. H. et al. Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S. Support Care Cancer 16, 791–801 (2008).

    Article 
    PubMed 

    Google Scholar 

  • Daly, B. et al. Analysis of a Remote Monitoring Program for Symptoms Among Adults With Cancer Receiving Antineoplastic Therapy. JAMA Netw. Open 5, e221078 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Alishahi Tabriz, A. et al. Trends and Characteristics of Potentially Preventable Emergency Department Visits Among Patients With Cancer in the US. JAMA Netw. Open 6, e2250423 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Carnio, S., Di Stefano, R. F. & Novello, S. Fatigue in lung cancer patients: symptom burden and management of challenges. Lung Cancer (Auckl.) 7, 73–82 (2016).

    PubMed 

    Google Scholar 

  • Mo, J. et al. Association of Fatigue and Outcomes in Advanced Cancer: An Analysis of Four SWOG Treatment Trials. JCO Oncol. Pr. 17, e1246–e1257 (2021).

    Article 

    Google Scholar 

  • The White House. Fact sheet: President Biden reignites cancer moonshot to end cancer as we know it, (2022).

  • National Plan Unveiled to Combat Cancer. Cancer Dis. 13, OF1. (2023)

  • Zon, R. T. et al. Telehealth in Oncology: ASCO Standards and Practice Recommendations. JCO Oncol. Pr. 17, 546–564 (2021).

    Article 

    Google Scholar 

  • Shah, A. et al. Digital Health Interventions for Depression and Anxiety Among People With Chronic Conditions: Scoping Review. J. Med. Internet Res. 24, e38030 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Elkefi, S., Trapani, D. & Ryan, S. The role of digital health in supporting cancer patients’ mental health and psychological well-being for a better quality of life: A systematic literature review. Int J. Med. Inf. 176, 105065 (2023).

    Article 

    Google Scholar 

  • Deleemans, J. M. et al. Recent Progress in Mind–Body Therapies in Cancer Care. Curr. Oncol. Rep. 25, 293–307 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Duan, L., Xu, Y. & Li, M. Effects of Mind-Body Exercise in Cancer Survivors: A Systematic Review and Meta-Analysis. Evid. Based Complement Altern. Med. 2020, 7607161 (2020).

    Article 

    Google Scholar 

  • Bower, J. E. et al. Management of Fatigue in Adult Survivors of Cancer: ASCO–Society for Integrative Oncology Guideline Update. J. Clin. Oncol. 42, 2456–2487 (2024).

    Article 
    PubMed 

    Google Scholar 

  • Wayne, P. M. et al. Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. J. Cancer Surviv. 12, 256–267 (2018).

    Article 
    PubMed 

    Google Scholar 

  • Carlson, L. E. et al. Mind-Body Therapies in Cancer: What Is the Latest Evidence? Curr. Oncol. Rep. 19, 67 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Bower, J. E. et al. Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. J. Clin. Oncol. 32, 1840–1850 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mao, J. J. et al. Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline. J. Clin. Oncol. 40, 3998–4024 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Carlson, L. E. et al. Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults With Cancer: Society for Integrative Oncology–ASCO Guideline. J. Clin. Oncol. 41, 4562–4591 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Bauml, J. M. et al. Do attitudes and beliefs regarding complementary and alternative medicine impact its use among patients with cancer? A cross-sectional survey. Cancer 121, 2431–2438 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Desai, K., Liou, K., Liang, K., Seluzicki, C. & Mao, J. J. Availability of Integrative Medicine therapies at National Cancer Institute Designated Comprehensive Cancer Centers and Community Hospitals. J. Alter. Complement Med. 27, 1011–1101 (2021).

    Article 

    Google Scholar 

  • Azizoddin, D. R. et al. Development and pre-pilot testing of STAMP + CBT: an mHealth app combining pain cognitive behavioral therapy and opioid support for patients with advanced cancer and pain. Support Care Cancer 32, 123 (2024).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Davies, F. et al. Uptake of an online psychological therapy program (iCanADAPT-Early) when implemented within a clinical pathway in cancer care centres. Psychooncology 31, 338–341 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Murphy, M. J. et al. Randomised controlled trial of internet-delivered cognitive behaviour therapy for clinical depression and/or anxiety in cancer survivors (iCanADAPT Early). Psychooncology 29, 76–85 (2020).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Romero, S. A. D. et al. Barriers to physical activity: a study of academic and community cancer survivors with pain. J. Cancer Surviv. 12, 744–752 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Desai, K. et al. Understanding interest, barriers, and preferences related to yoga practice among cancer survivors. Support Care Cancer 29, 5313–5321 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Romero, S. A. D. et al. The association between fatigue and pain symptoms and decreased physical activity after cancer. Support Care Cancer 26, 3423–3430 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Emard, N. et al. Virtual Mind-Body Programming for Patients With Cancer During the COVID-19 Pandemic: Qualitative Study. JMIR Cancer 7, e27384 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Willems, R. A., Mesters, I., Lechner, L., Kanera, I. M. & Bolman, C. A. W. Long-term effectiveness and moderators of a web-based tailored intervention for cancer survivors on social and emotional functioning, depression, and fatigue: randomized controlled trial. J. Cancer Surviv. 11, 691–703 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lee, K. et al. Digital Health Interventions for Adult Patients With Cancer Evaluated in Randomized Controlled Trials: Scoping Review. J. Med Internet Res. 25, e38333 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Aapro, M. et al. Digital health for optimal supportive care in oncology: benefits, limits, and future perspectives. Support Care Cancer 28, 4589–4612 (2020).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Shaffer, K. M. et al. Digital health and telehealth in cancer care: a scoping review of reviews. Lancet Digit Health 5, e316–e327 (2023).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Woodcock, J. & LaVange, L. M. Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both. N. Engl. J. Med. 377, 62–70 (2017).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • U.S. Department of Health & Human Services & National Cancer Institute. (National Cancer Institute, 2023).

  • Temel, J. S., Pirl, W. F., Recklitis, C. J., Cashavelly, B. & Lynch, T. J. Feasibility and Validity of a One-Item Fatigue Screen in a Thoracic Oncology Clinic. J. Thorac. Oncol. 1, 454–459 (2006).

    Article 
    PubMed 

    Google Scholar 

  • Butt, Z. et al. Use of a single-item screening tool to detect clinically significant fatigue, pain, distress, and anorexia in ambulatory cancer practice. J. Pain. Symptom Manag. 35, 20–30 (2008).

    Article 

    Google Scholar 

  • Schag, C. C., Heinrich, R. L. & Ganz, P. A. Karnofsky performance status revisited: reliability, validity, and guidelines. J. Clin. Oncol. 2, 187–193 (1984).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Mendoza, T. R. et al. The rapid assessment of fatigue severity in cancer patients: use of the brief fatigue inventory (English). Cancer 85, 1186–1196 (1999).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Mendoza, T. R. et al. Assessment of fatigue in cancer patients and community dwellers: validation study of the Filipino version of the brief fatigue inventory. Oncology 79, 112–117 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Bruera, E., Kuehn, N., Miller, M. J., Selmser, P. & Macmillan, K. The Edmonton Symptom Assessment System (ESAS): a simple method for the assessment of palliative care patients. J. Palliat. Care 7, 6–9 (1991).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Hui, D. et al. Minimal clinically important differences in the Edmonton Symptom Assessment Scale in cancer patients: A prospective, multicenter study. Cancer 121, 3027–3035 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Zimmermann, C. et al. Nurse and physician inter-rater agreement of three performance status measures in palliative care outpatients. Support Care Cancer 18, 609–616 (2010).

    Article 
    PubMed 

    Google Scholar 

  • Bastien, C. H., Vallieres, A. & Morin, C. M. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep. Med. 2, 297–307 (2001).

    Article 
    PubMed 

    Google Scholar 

  • Morin, C. M., Belleville, G., Belanger, L. & Ivers, H. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep 34, 601–608 (2011).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Savard, M. H., Savard, J., Simard, S. & Ivers, H. Empirical validation of the Insomnia Severity Index in cancer patients. Psychooncology 14, 429–441 (2005).

    Article 
    PubMed 

    Google Scholar 

  • Zigmond, A. S. & Snaith, R. P. The Hospital Anxiety and Depression Scale. Acta Psychiatr. Scand. 67, 361–370 (1983).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Hays, R. D., Bjorner, J. B., Revicki, D. A., Spritzer, K. L. & Cella, D. Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual. Life Res. 18, 873–880 (2009).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Revicki, D. A. et al. Predicting EuroQol (EQ- 5D) scores from the patient-reported outcomes measurement information system (PROMIS) global items and domain item banks in a United States sample. Qual. Life Res. 18, 783–791 (2009).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Trevino, K. M. et al. Rapid deployment of virtual mind-body interventions during the COVID-19 outbreak: feasibility, acceptability, and implications for future care. Support Care Cancer 29, 543–546 (2021).

    Article 
    PubMed 

    Google Scholar 

  • Tomlinson, D., Diorio, C., Beyene, J. & Sung, L. Effect of Exercise on Cancer-Related Fatigue: A Meta-analysis. Am. J. Phys. Med Rehabil. 93, 675–686 (2014).

    Article 
    PubMed 

    Google Scholar 

  • Liu, G. F., Lu, K., Mogg, R., Mallick, M. & Mehrotra, D. V. Should baseline be a covariate or dependent variable in analyses of change from baseline in clinical trials? Stat. Med. 28, 2509–2530 (2009).

    Article 
    PubMed 

    Google Scholar 

  • Feingold, A. A Regression Framework for Effect Size Assessments in Longitudinal Modeling of Group Differences. Rev. Gen. Psychol. 17, 111–121 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Mallinckrod, C. H., Lane, P. W., Schnell, D., Peng, Y. & Mancuso, J. P. Recommendations for the Primary Analysis of Continuous Endpoints in Longitudinal Clinical Trials. Drug Inf. J. 42, 303–319 (2008).

    Article 

    Google Scholar 

  • Laird, N. M. & Ware, J. H. Random-effects models for longitudinal data. Biometrics 38, 963–974 (1982).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Diggle, P., Heagerty, P., Liang, K.-Y. & Zeger, S. Analysis of Longitudinal Data. (Oxford University Press, Oxford, 2002).

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